Skip to content

Integrated single cell RNA sequencing and metabonomics reveals the biomarkers and metabolites in blood of patients with acute ischemic stroke

Integrated single cell RNA sequencing and metabonomics reveals the biomarkers and metabolites in blood of patients with acute ischemic stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200061974
Enrollment
Unknown
Registered
2022-07-14
Start date
2022-07-14
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic stroke

Interventions

None listed

Sponsors

Hainan Provincial Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of AIS; 2. Between 40 and 80 years old; 3. Anterior circulation infarction caused by various reasons; 4. Thrombolysis and thrombectomy have not been performed, or thrombectomy has not been successful; 5. Patients with mild AIS (NIHSS = 6) and large vessel occlusion events in the anterior circulation (MRA or CTA shows large vessel occlusion or subtotal occlusion, or DSA shows TICI <= 2a).

Exclusion criteria

Exclusion criteria: 1. Patients with severe liver, kidney, lung, tumor and other diseases; 2. Patients with any form of cerebral hemorrhage; 3. Simple lacunar infarction or cerebral infarction caused by posterior circulation; 4. Taking antibiotics within 3 days before admission, major trauma or surgical events, inflammation, and glucocorticoid treatment history within 28 days; 5. Patients with stroke, thrombectomy and recanalization, and old infarction caused by infection, blood disease, liver and kidney insufficiency, and other causes; 6. Pregnant and lactating women, those who are allergic to the drugs used and those with mental disorders; 7. Diabetic patients.

Design outcomes

Primary

MeasureTime frame
single cell RNA sequencing;metabonomics;

Countries

China

Contacts

Public ContactYong Gu

Hainan Provincial Hospital of Traditional Chinese Medicine

yonggu@hainmc.edu.cn+86 15521280288

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026