spinal cord injury
Conditions
Interventions
Experimental group:Basic treatment + symptomatic treatment + laminectomy + human umbilical cord mesenchymal cell transplantation
Control group :Basic treatment + symptomatic treatment + laminectomy + normal saline
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 13-65 years old, gender is not limited, body mass index (BMI) between 19-25 kg/m2 (BMI = weight (kg)/height (m) square), including the boundary value; 2. Meet the diagnostic criteria for traumatic spinal cord injury; 3. Sensory or motor loss below the level of injury; 4. Have not received stem cell therapy in the last 6 months; 5. The subjects themselves or their family members can sign the informed consent form according to the research procedures and instructions.
Exclusion criteria
Exclusion criteria: 1. Only symptoms of nerve root injury; 2. Only symptoms of cauda equina injury; 3. The mean arterial pressure (MAP) is less than 60 mmHg; 4. Glasgow score less than 13 points; 5. Pregnant, lactating women or women planning to become pregnant; 6. Under the age of 13 or over the age of 65 years; 7. The patient and his/her family members refuse to sign the test consent form; 8. The patient has a history of medical diseases with potential risks: history of diabetes, history of severe cardiovascular disease, concurrent serious infection focus, history of gastrointestinal bleeding, etc.; 9. Serum HIV antibody positive, syphilis antibody positive; 10. Patients with severe mental illness and cognitive impairment; 11. Other serious systemic or organ diseases; 12. Participated in other clinical research in the past 3 months; 13. The investigator believes that there are patients who cannot be included in this study for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ASIA Spinal cord injury Score;IANR Spinal Cord Injury Function Assessment Scale;Functional Independence Assessment (FIM) Scale;Spinal Cord Injury Walking Index (WISCI);Neuroelectrophysiological examination;Bladder function;Imaging and ultrasound examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine laboratory examination; | — |
Countries
China
Contacts
Public ContactFeng Shiqing
Tianjin Medical University General Hospital
Outcome results
None listed