endometrial polyp
Conditions
Interventions
Experimental group:Doxycycline
Control group:Placebo
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 20-45 years; 2. Multiple endometrial polyps were diagnosed under hysteroscopy; 3. Hysteroscopy conforms to the clinical manifestations of chronic endometritis and the pathology conforms to the diagnostic criteria of chronic endometritis; 4. Uterine shape and endometrial development are normal; 5. No doxycycline or pregnancy contraindications; 6. Did not receive antibiotic treatment such as doxycycline within 1 month before enrollment; 7. Have not participated in other clinical research, and after fully understanding all the risks and inconveniences brought by this trial, are willing to follow the trial arrangement and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Intrauterine adhesions or uterine deformities, or combined with uterine organic lesions; 2. Infertility caused by other reasons such as tubal factors; 3. Menorrhagia, anemia, irregular menstruation 4. Simple hyperplasia and above endometrial lesions 5. People with mental or consciousness disorders; 6. Combined with severe chronic diseases (heart, lung, liver, kidney dysfunction); 7. Pregnant or lactating women; 8. Malignant tumors; 9. Allergic to the test drug or unable to tolerate the test check; 10. Failure to complete follow-up visits on a regular basis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence rate;Miscarriage rate;Differences in uterine cavity flora;Symptoms of abnormal uterine bleeding; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy Rate;Live birth rate; | — |
Countries
China
Contacts
Public ContactHuiying Zhang
Tianjin Medical University General Hospital
Outcome results
None listed