Postoperative depression
Conditions
Interventions
Group 1 :Postoperative analgesic pump with esketamine 0.5 mg/kg
Group 2:placebo
Sponsors
Wenzhou People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients with hip fractures of the femoral neck, femoral trochanter, femoral intertrochanter or within 5 cm below the trochanter who are older than or equal to 65 years old; 2. Elective surgery for fracture treatment; 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Concurrent with multiple injuries of the whole body; 2. Contraindications to anesthesia or surgery; 3. Unable to communicate effectively due to coma, dementia and other diseases before operation; 4. There are contraindications to esketamine; multiple operations during hospitalization; 5. Participate in other clinical trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton depression scale, HAMD;Geriatric Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale, VAS;Self-controlled analgesia frequency;serum brain derived neurotrophic factor, BDNF;serum 5-HT;Activity of Daily Living Scale, ADL; | — |
Countries
China
Contacts
Public ContactCai Jiajing
Wenzhou People's Hospital
Outcome results
None listed