Intracranial atherosclerotic diseases
Conditions
Interventions
None listed
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. ICAS group: (1) Age 18-85 years; (2) The branches of Willis ring (ICA\MCA\ACA\PCA\BA or VA) were more than 50% or occluded by head MRA or CTA; (3) mRS <= 2 (0 means asymptomatic, 6 means dead); (4) Patients enrolled in PCSK9 inhibitor sub-study should meet the history of acute ischemic stroke on the symptomatic side (NIHSS score 1-15 within 7 days of onset); (5) Agree to participate in the research and sign the informed consent form; 2. Healthy control group: (1) Age 18-85 years; (2) No branch vessels of Willis ring (ICA\MCA\ACA\PCA\BA or VA) were found in MRA or CTA of the head, which were more than 50% or occluded; (3) No history of stroke /TIA; (4) No cognitive impairment; (5) No history of brain trauma or brain tumor; (6) Agree to participate in the research and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Extracranial vascular stenosis > 50%; 2. There are contraindications to magnetic resonance imaging (metal in the body, claustrophobia); 3. Other known causes of non-atherosclerotic intracranial artery stenosis, including dissection, vasculitis, moyamoya disease, embolism, immune system diseases, etc.; 4. Other known causes of stroke, such as cerebral hemorrhage/SAH, cardiogenic embolism, etc.; 5. Neurodegenerative diseases such as Alzheimer's disease, Lewy body dementia, frontotemporal degeneration and Parkinson's disease have been diagnosed; 6. History of brain trauma, multiple sclerosis, encephalitis, tumor, poisoning, syphilis, serious heart, lung, liver, kidney and endocrine diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ischemic stroke;cognitive impairment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale;daily living ability;other acute vascular events (new cerebral hemorrhage/subarachnoid hemorrhage, myocardial infarction, visceral hemorrhage, heart failure, pulmonary embolism, arrhythmia, etc.);vascular death events (death from ischemic/hemorrhagic stroke, myocardial infarction, visceral hemorrhage, heart failure, pulmonary embolism, sudden death, arrhythmia, etc.); | — |
Countries
China
Contacts
Public ContactXu Weihai
Department of Neurology, Peking Union Medical College Hospital
Outcome results
None listed