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Probiotic spray for oropharyngeal gonorrhoea treatment in men who have sex with men: a randomised controlled trial

Probiotic spray for oropharyngeal gonorrhoea treatment in men who have sex with men: a randomised controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061928
Enrollment
Unknown
Registered
2022-07-11
Start date
2022-07-15
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oropharyngeal gonorrhoea

Interventions

Experimental group:Probiotics combined with lactic acid
Control group:Probiotics placebo combined with lactic acid

Sponsors

Xi'an Jiaotong University Health Science Center
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Male; 2. Age more than 18 years; 3. Man who had sex with a man in the past; 4. The throat swab was positive for Neisseria gonorrhoeae; 5. Man was diagnosis as Neisseria gonorrhoeae or chlamydia at anorectum who are willing to choose lactic acid gel for treatment.

Exclusion criteria

Exclusion criteria: 1. Man who have taken antibiotics in the past 2 weeks; 2. Man who have taken probiotics in the past 1 week; 3. Man was diagnosis as Neisseria gonorrhoeae or chlamydia at urethra; 4. Man was diagnosis as chlamydia atoropharynx; 5. Man had a positive result for syphilis on the day of screening; 6. Man perferred to antibiotics treatment.

Design outcomes

Primary

MeasureTime frame
Cure rate for oropharyngeal gonorrhoea after 2 weeks;Cure rate for oropharyngeal gonorrhoea after 1 week;

Secondary

MeasureTime frame
Oropharyngeal Neisseria gonorrhoeae load after 3 days;Oropharyngeal Neisseria gonorrhoeae load after 10 minutes;Oropharyngeal Neisseria gonorrhoeae load after 30 minutes;Oropharyngeal Neisseria gonorrhoeae load after 60 minutes;Oral flora;

Countries

China

Contacts

Public ContactLei Zhang

Xi'an Jiaotong University Health Science Center

lei.zhang1@xjtu.edu.cn+86 2982655135

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026