Infant immunity and gastrointestinal function
Conditions
Interventions
Group 1 :artificially fed and fed synbiotics combined with lactobridgetin combined with synbiotics infant formula milk powder
Group 2:artificially fed with synbiotics and synbiotics infant formula without lactopontin
Group 3:artificially fed, fed with lactophysin added syngenicity infant formula and did not use probiotics
Group 4:exclusive breastfeeding
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Infants from 2 to 9 months; 2. Full-term infants, 37 weeks = 2500 grams, <= 4000 grams; 4. Single birth; 5. Babies with normal pregnancy and vaginal delivery; 6. Have not used food or drugs that affect intestinal flora and metabolites within 1 month, mainly including probiotics, infant formula supplemented with lactopontin, and antibiotics.
Exclusion criteria
Exclusion criteria: 1. Patients with diseases requiring mechanical ventilation or drug treatment within one week after birth (excluding infantile jaundice patients treated with blue light); 2. Children with serious diseases such as heart, liver, kidney, hematopoietic system or metabolic genetics; 3. Those who affect feeding or metabolism due to body defects; 4. Patients with milk allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stool routine;Fecal intestinal flora detection;Determination of fecal short-chain fatty acids;fecal secretory immunoglobulin A;Urine routine;Blood routine;Lymphocyte subgroup;Cell factor;Height;Weight;Head circumference;Upper arm circumference;Incidence of infectious diseases;Occurrence of gastrointestinal events;Allergic condition; | — |
Countries
China
Contacts
Public ContactYe Yanbin
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed