Kidney transplant
Conditions
Interventions
Group 1:Dex 0.25 ug/kg/h was continuously pumped until the end of operation
Group 2:Dex 0.5 ug/kg/h was pumped continuously until the end of operation
Group 3:Constant volume 0.9% NS was pumped until the end of operation
Sponsors
The Second Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Obtain informed consent; 2. First renal transplant patients; 3. Age 18-65 years old; 4. 45 kg <= weight <= 90 kg; 5. ASA III level.
Exclusion criteria
Exclusion criteria: 1. Patients receiving other organ transplants; 2. Kidney donors with incompatible ABO blood types; 3. PRA > 10%; 4. Identify transplant failures due to rejection or surgical reasons; 5. Severe heart, lung and liver diseases; 6. History of neurological and mental diseases, long-term use of sedative drugs; 7. Patients with sick sinus syndrome, atrioventricular block, and sinus bradycardia; 8. The researcher thinks that it is not suitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative monocyte levels in renal transplantation patients;Proinflammatory factors (TNF-a, IL-1ß, IL-6);renal function;Anti-inflammatory factors (IL-4, IL-10);Perioperative dendritic cell level in renal transplantation patients;Perioperative levels of macrophage-derived exosomes in renal transplantation patients; | — |
Countries
China
Contacts
Public ContactMing Shaopeng
Department of Anesthesiology, Second Affiliated Hospital of Guangxi Medical University
Outcome results
None listed