Postpartum obesity
Conditions
Interventions
App push management + Smiglutide intervention group:App based on lifestyle push intervention, combined with smiglutide treatment
App management feedback group:App provides lifestyle intervention and timely feedback
App push management group:App carries out lifestyle push intervention
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-45 years, not breastfeeding within 1 year after delivery; 2. Body mass index (BMI) >= 28 kg/m^2; 3. Those who are diagnosed with gestational diabetes mellitus; 4. Those who are diagnosed with gestational hypertension, preeclampsia or eclampsia; 5. A person who has a negative pregnancy test and is able to adhere to contraception during the test; 6. Follow-up conditions, compliance, and voluntary subjects who signed informed consent. Except for one of the conditions that 3 and 4meet, all other conditions must be met at the same time.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: 1. Previous abnormal history of blood glucose, blood pressure, and serum lipids; 2. Uncontrolled thyroid disease (thyroid-stimulating hormone (TSH) > 6.0 mIU/L or 2 times the upper limit of normal level or calcitonin >= 100 ng/L); 4. Impaired liver function (hepatic transaminases > 3 times the upper limit of normal level); 5. Impaired renal function (estimated glomerular filtration rate (eGFR) = 1.4 mg/dL); 6. History of heart disease: decompensated heart failure (NYHA: grade III or IV), unstable angina, and/or myocardial infarction within the past 12 months; 7. Previous surgical treatment of weight loss and postpartum treatment with anti-obesity drugs; 8. Allergy to GLP-1 RA; 9. Severe mental illnesses, including depression, schizophrenia, paranoid psychosis, bipolar disorder or mental retardation; 10. History of neurological disorders, including traumatic brain surgery; 11. Bleeding disorders; 12. Postpartum treatment with GLP-1 RA. Suspension or withdrawal of criteria: 1. The occurrence of intolerable drug-related adverse events; 2. Subjects do not follow the study procedure; 3. The subject is pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body weight change; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin resistance;Ambulatory blood pressure;serum lipids;body fat percentage;Neonatal growth and development;Women's health-related quality of life, psychological indicators; | — |
Countries
China
Contacts
Public ContactHan Cha
Tianjin Medical University General Hospital
Outcome results
None listed