Effects of pretreatment with a small dose of esketamine on sufentanil-induced cough during induction of general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200061894

Enrollment

Unknown

Registered

2022-07-07

Start date

2022-07-15

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sufentanil-induced cough

Interventions

control group:Esketamine intervention group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 100 patients with ASA physical status I-II aged 18-65 years, weighing between 40 and 80 kg,and scheduled for elective surgery during general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Body weight exceeding 20% of the ideal body weight; 2. History of liver or kidney impairment; 3. Increased intracranial, intraabdominal or intraocular pressure before operation, depression, smoking, asthma, chronic cough, upper respiratory tract infection within one month of surgery; 4. Use of medications that could interfere with this study such as angiotensin-converting enzyme inhibitors, antidepressants, bronchodilators or steroidsa; 5. History of gastroesopha-geal reflux, hypertension, diabetes, heart disease.

Design outcomes

Primary

Measure	Time frame
the cough times within 1 min, mean arterial pressure (MAP) and heart rate (HR);	—

Countries

China

Contacts

Public ContactXueyue Zhou

Air Force Medical Center, Chinese People's Liberation Army

19913141191@163.com+86 19913141191

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026