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An investigation of the central pathological mechanisms associated with chronic nonspecific low back pain based on multimodal magnetic resonance imaging

Multimodal magnetic resonance imaging, the central pathological mechanisms of chronic nonspecific low back pain

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200061881
Enrollment
Unknown
Registered
2022-07-06
Start date
2022-07-05
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Nonspecific Low Back Pain

Interventions

CNLBP Group:N/A
Healthy controls:N/A

Sponsors

College of Rehabilitation Medicine, Fujian University of TCM
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria of CNLBP group 1. Meeting the diagnostic criteria of CNLBP: the course of disease lasts for more than 12 weeks, and the pain and discomfort below the costal margin, above the hip transverse line and between the midaxillary line of both sides are caused by reasons other than spine-specific disease and nerve root pain, with or without referred pain in the thigh; 2. Aged 18-60 years; 3. Right-handedness (Using the Edinburgh handedness inventory as the criterion); 4. At least one attack in the last 2 weeks; 5. The average score of visual analog scale (VAS) >= 3 in the past 7 days; 6. The subject agrees to participate in the study and signs the informed consent. Inclusion criteria of healthy control group 1. Aged 18-60 years, and age and sex were roughly matched with CNLBP group; 2. Right-handedness (Using the Edinburgh Handedness Scale as the criterion); 3. Previous health, no history of chronic pain disease; 4. Beck Depression Inventory 2nd Edition (BDI-?) score <= 13; 5. Beck Anxiety Inventory (BAI) score < 45; 6. The subject agrees to participate in the study and signs the informed consent.

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating women; 2. The Mini-Mental State Examination (MMSE) score < 27; 3. Previous history of surgery or lumbar fracture, or diseases related to the nervous system; 4. Presence of other chronic musculoskeletal pain disorders; 5. Previous history of alcohol or psychotropic drug abuse or diagnosed history of mental disorders and family history; 6. The subject with claustrophobia or metal implants and other contraindications for MRI examination; 7. Have taken sleeping, analgesic, antidepressant or sedative drugs in the past 2 weeks; 8. Unable to cooperate with the evaluation and MRI examination for other reasons; 9. Participants in other clinical trials that influence the evaluation of the study results.

Design outcomes

Primary

MeasureTime frame
MRI;—

Countries

China

Contacts

Public ContactJiang Zheng

College of Rehabilitation Medicine, Fujian University of TCM

949273304@qq.com+86 13559458154

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026