postoperative pain
Conditions
Interventions
control group:NO
experimental group:Intravenous administration of esketamine
Sponsors
Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with central sensitization underwent high tibial osteotomy; 2. BMI 18.5-24.0 kg/m2, no gender, ASA grade I-?, aged >= 45 years.
Exclusion criteria
Exclusion criteria: 1. Previous recovery history of surgery and anesthesia; 2. Diabetes; 3. Alcohol abusers; 4. Smokers; 5. Patients who are allergic to the active ingredient of ketamine or all excipients; 6. Long-term oral painkillers due to chronic pain; 7. Abnormal liver and kidney function; 8. Previous history of serious cardiovascular and cerebrovascular diseases (grade II or III hypertension, old myocardial infarction, heart failure, angina pectoris, arrhythmia, valvular heart disease, old cerebral infarction; lacunar cerebral infarction, ischemic stroke); 9. History of lung disease; 10. Patients with severe visual and hearing impairment; 11. Unable to communicate normally; 12. Delirium, dementia, Alzheimer's disease and Parkinson's disease; 13. Those who do not cooperate cannot complete the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CSI, Central Sensitization Inventory;VAS, Visual Analogue Scale/Score;Number of analgesic pump presses; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery quality score; | — |
Countries
China
Contacts
Public ContactWang Qiujun
The Third Hospital of Hebei Medical University
Outcome results
None listed