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Effectiveness of endoscopic transoral medial pterygomandibular fold approach for retropharyngeal lymph node dissection: a prospective, single-arm clinical trial

Endoscopic transoral medial pterygomandibular fold approach for retropharyngeal lymph node dissection

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061867
Enrollment
Unknown
Registered
2022-07-05
Start date
2022-06-21
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recurrent nasopharyngeal carcinoma

Interventions

Endoscopic transoral medial pterygomandibular fold approach:Case series

Sponsors

Eye & ENT Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of malignant tumor of nasopharynx or skull base; 2. Metastatic retropharyngeal lymph nodes for image findings; 3. Stage rT1,rT2,rT3 or rT4 and surgically resectable; 4. Aged >= 18 years; 5. Sign of inform consent on metastatic retropharyngeal lymph nodes resection; 6. No risk of recent bleeding; 7. Without distant metastasis; 8. Sufficient organ function; 9. General physical condition can tolerate general anesthesia.

Exclusion criteria

Exclusion criteria: 1. With distant metastasis; 2. With uncontrolled intercurrent illnesses which will interfere with the ability to undergo therapy; 3. With prior malignancy (excluding adequately treated basal cell or squamous cell skin cancer, in-situ cervical cancer); 4. Any contradiction to surgery; 5. With serious autoimmune disease; 6. Have any co-existing condition that would preclude full compliance or safety with the study; 8. Presence of a significant neurological or psychiatric disease, including dementia and seizures; 7. Presence of a significant neurological or psychiatric disease, including dementia and seizures; 8. Uncontrolled infectious diseases; 9. Female patients who are at pregnancy or lactation; 10. Without personal freedom or independent civil capacity; 11.Other situations that are not suitable for grouping.

Design outcomes

Primary

MeasureTime frame
R0 resection rate of surgery;

Secondary

MeasureTime frame
Total resection rate of imaging;surgery-related complications;life quality;disease-free survival;

Countries

China

Contacts

Public ContactYu Hongmeng, Sun Xicai

Eye & ENT Hospital of Fudan University

hongmengyush@fudan.edu.cn+86 21 64377134

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026