quallity of life
Conditions
Interventions
Ibuprofen 400 mg group:Ibuprofen injection 4 ml+Ibuprofen injection mock-up 4 ml
Ibuprofen 800 mg group:Ibuprofen injection 8 ml
Control Group:Ibuprofen injection mock-up 4 mlx2
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective general anesthesia; 2. ASA health status class I-II; 3. 18 kg/m2 < BMI < 30 kg/m2; 4. Aged 18-70 years, regardless of gender; 5. No intravenous infusion disorder; 6. Voluntary subjects who signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of head trauma, intracranial surgery or stroke within 4 weeks prior to surgery, or those with combined organic lesions of the central nervous system and impaired consciousness; 2. Patients requiring lumbar spine surgery and liver resection; 3. Patients requiring admission to the Surgical Intensive Care Unit (SICU) after surgery; 4. Patients with high bleeding risk, including patients with congenital bleeding disorders (e.g., hemophilia), patients with thrombocytopenia (platelet count less than 100x10^9/L) or abnormal platelet function, and patients with coagulation disorders (PT or APTT higher than the upper limit of normal); 5. Patients with a history of asthma and heart failure, and patients who have undergone organ transplantation; 6. Patients with uncontrolled grade 2 or higher hypertension (SBP >= 160 mmHg or DBP>= 100 mmHg) or hypertension on ACEI and diuretics for 30 days or more; 7. Those with a prior history of benign peptic ulcers/bleeding (except at surgical sites); 8. Those with a clear previous history of cardiovascular disease, liver (ALT or AST > 1.5 times the upper limit of normal value), kidney (Cr > upper limit of normal value) functional abnormalities, serious primary diseases such as endocrine system, and psychiatric patients; 9. Patients with perioperative pain during coronary artery bypass graft surgery (CABG); 10. Patients with a history of gastrointestinal bleeding or perforation after application of NSAIDs; 11. Patients who have used acetaminophen within 6h prior to surgery or non-steroidal anti-inflammatory drugs (NSAIDs) within 12h; 12. Patients who have used other analgesics within 24h prior to surgery; 13. Patients who have used anticoagulant or antiplatelet drugs such as warfarin or clopidogrel for a long time (more than three months); 14. Those who are taking methotrexate and other drugs that have increased toxicity due to interaction with the test drug; 15. Patients who are allergic to ibuprofen or arginine and those who have experienced asthma, urticaria or allergic reactions after taking aspirin, COX-2 inhibitors and other NSAIDs; 16. Women who are pregnant or lactating; 17. Patients with narcotic drug dependence or opioid tolerance prior to enrollment; 18. Patients enrolled in other clinical studies within 3 months prior to surgery; 19. Patients with other conditions deemed unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Health utility value ;TICS-m score; | — |
Countries
China
Contacts
Public ContactOuyang Wen
The Third Xiangya Hospital
Outcome results
None listed