Observe the Effects of Multiple Intravitreal anti-VEGF Injections on Corneal Nerve Fiber and Sensitivity

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200061819

Enrollment

Unknown

Registered

2022-07-03

Start date

2022-06-20

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinopathy

Interventions

case series:NIL

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 or older,types of disease included age-related macular degeneration, macular edema caused by retinal vein occlusion, and diabetic macular edema; 2. At least three intravitreal anti-VEGF injections; 3. Follow-up was over 3 months.

Exclusion criteria

Exclusion criteria: 1. Trauma or ophthalmic surgery such as intravitreal drug injection therapyrefractive surgery and others; 2. Abnormal corneal structure; 3. History of contact lens use, dry eye disease, prolonged topical ocular medication (artificial tears are excluded); 4. Glaucoma diagnosis and subjects with anterior-segment disease; 5. Patients lost to follow-up.

Design outcomes

Primary

Measure	Time frame
Corneal nerve parameter;Corneal sensitivity;	—

Countries

China

Contacts

Public ContactJingjing Zhang

Shandong Eye Hospital

vitreo_retina@126.com+86 15965633553

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026