breast cancer
Conditions
Interventions
Group E (Esketamine):a bolus injection of 0.2 mg/kg followed by continous infused with 0.1 mg/kg/h to seam skin
Group C (placebo ):a bolus injection of normal saline followed by continous infused of the same volume with Group E to seam skin
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Planned breast cancer surgery (modified radical mastectomy or extensive local resection, axillary lymph node dissection); 2. Female, aged 18-65; 3. ASA I-III; 4. BMI: 18.5-28 kg/m2; 5. Be able to understand this study and sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Serious cardiovascular diseases, poorly controlled hypertension, hyperthyroidism; 2. Kidney or liver dysfunction; 3. Neurocognitive or mental disorders; 4. Epilepsy; 5. Allergic to study drugs; 6. Drug or alcohol abuse; 7. With severe sleep apnea syndrome; 8. Recently used sedative and analgesic drugs; 9. Take sleeping pills the night before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RCSQ, Richards Campbell Sleep Questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| PSQI, Pittsburgh sleep quality index;VAS, Visual Analogue Scale/Score;SF-MPQ, Short-Form McGill Pain Questionnaire; | — |
Countries
China
Contacts
Public ContactWenxuan Zhang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed