Impairment of cardiac function and cognitive function under cardiopulmonary bypass
Conditions
Interventions
The experimental group:Before anesthesia induction, dexmedetomidine was given with a load of 0.5µg/kg for 10min, followed by continuous pumping at 0.5ug/kg/h until the end of surgery, and continued pu
The control group: pump normal saline in the same manner at the same volume and speed
Sponsors
Army Specialty Medical Center of PLA
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing cardiopulmonary bypass valve replacement and annulus valvuloplasty; 2. Aged 30-65; 3. ASA:II~III;NYHA: II~III; 4. Liver and kidney function are normal; 5. Informed consent; 6. There were no mental or neurological disorders before surgery.
Exclusion criteria
Exclusion criteria: 1. History of atrioventricular block, sinus bradycardia, and cerebral infarction; 2. LVEF< 35% ; 3. Patients with neurological diseases, cerebrovascular diseases or craniocerebral trauma before surgery; 4. Long-term use of sedatives or alcohol; 5. Secondary transit, secondary surgery or perioperative death; 6. Mental illness or inability to cooperate with the investigator; 7. Patients with incomplete data collection1.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTnT;CK-MB;MDA;SOD; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function assessment; | — |
Countries
China
Contacts
Public ContactYi Hu
Outcome results
None listed