gut microbiota
Conditions
Interventions
Mirabilite plus probiotics intervention group:Mirabilite plus probiotics intervention
Mirabilite plus placebo control group:Mirabilite plus placebo
PEG plus probiotic intervention group:PEG plus probiotic intervention
PEG plus placebo control group:PEG plus placebo
Sponsors
The Department of Gastroenterology, Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 with normal body mass index (17-28 kg/m^2), Han nationality, male and female; 2. No underlying diseases without taking probiotics within one month; 3. No participation in other clinical trials within 3 months; 4. No bowel arrival preparation has been made in the last month.
Exclusion criteria
Exclusion criteria: 1. History of pregnancy and serious acute and chronic diseases (especially gastrointestinal diseases); 2. Use drugs known to affect gastrointestinal motility, such as opioids and constipation drugs; 3. antibiotics were used 3 months before the experiment; 4. Taking laxatives, antilaxatives and gastrointestinal motility drugs within the past 1 week; 5. Patients with intestinal obstruction, intestinal perforation, gastric retention, active gastrointestinal bleeding, toxic enteritis, toxic megacolon, giant colonic polyp (diameter > 3cm), volvulus, and severe ulcerative colitis; 6. severe cardiac insufficiency; Alanine aminotransferase was more than 2 times of normal value and creatinine was abnormal. Have hematopoietic system and endocrine system and other primary diseases; A psychopath; 7. The patient participated in other clinical trials within 3 months; 8. People with allergic constitution and those who are allergic to the known ingredients of this drug or control drug; 9. Suspected or confirmed history of alcohol and drug abuse; 10. The investigator identified patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of species composition and diversity of intestinal flora; | — |
Countries
CHINA
Contacts
Public ContactMingming Deng
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed