Hypertension
Conditions
Interventions
Intervention group:Take antihypertensive drugs and Aerobic exercise
Routine treatment group :Take antihypertensive drugs
Sponsors
The Second Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of resistant hypertension in accordance with the American Heart Association scientific statement,62. i.e. to have a mean systolic blood pressure of =130 mm Hg on 24-hour ambulatory blood pressure monitoring and/or >= 135 mm Hg during the day time hours, while taking maximally tolerated doses of at least three antihypertensive agents including a diuretic; or to have a controlled blood pressure with four or more antihypertensive agents62. 2. Men or women. 3. Age: 35 to 75 years old. 4. Unchanged medication in the previous 3 months. 5. Willing to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary hypertension; 2. Evidence of target organ damage; 3. Patients with heart failure; 4. Previous cardiovascular event ; 5. Peripheral artery disease; 6. Renal failure; 7. Chronic obstructive pulmonary disease; 8. Systolic office blood pressure superior to 180 mmHg; 9. Biomechanical limitations to physical activity; 1O. Those participating in regular physical activity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Office BP;Cardiopulmonary function;Quality of life;Arteriosclerosis;Autonomic nerve function;Body composition;Endothelial factor;Inflammatory factor; | — |
Countries
China
Contacts
Public ContactXiaokang Wu
Outcome results
None listed