Allergic rhinitis
Conditions
Interventions
Allergic rhinitis:None
Healthy group:None
Sponsors
Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Health group inclusion criteria: Meet health standards determined by WHO (WORLD HEALTH ORGANIZATION. What is the WHO definition of health? [EB/OL]. [2017-04-26]. http://www.who.int /suggestions/faq/en/.) 2. Inclusion criteria for allergic rhinitis cases: (1) The patients were aged from 18 to 50 years old and met the diagnostic criteria for allergic rhinitis in the "Guidelines for the Diagnosis and Treatment of Allergic rhinitis in China" (revised edition, 2022). On this basis, the internationally accepted Score for Allergic Rhinitis (SFAR) scale was used to evaluate the patients. If the SFAR Score was greater than or equal to 7, the patients were eligible for inclusion.[Annesi-Maesano, A. Didier, M. Klossek, et al. The score for allergic rhinitis (SFAR): a. simple and valid assessment method in population studies[J] Allergy,2002,57(2): 107 -114.]Willing to participate in the study, as the disease group, agree to take biological samples. (2) Has lived in Tianjin for more than 1 year and has no long-term travel plan during the study period.
Exclusion criteria
Exclusion criteria: Exclusion criteria for allergic rhinitis: 1. Patients with smoking behavior; 2. patients with serious lung disease; 3. patients who take medication continuously for a long time; 4. Patients with occupational exposure to dust and organic matter; 5. Residential decoration patients within the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood serum Mel;Blood serum MT1;Blood serum MT2;Blood serum IL-4;Blood serum p-JAK1;Blood serum p-STAT6;Blood serum IgE;Blood serum IL-5;Blood serum IL-6;Blood serum IL-10;Blood serum IL-13;Blood serum IL-17;Blood serum IFN-?;Blood serum HIS;Peripheral blood Th2 cells;Peripheral blood JAK1 gene DNA methylation;Peripheral blood STAT6 gene DNA methylation;Peripheral blood Eosinophils;Nasal lavage fluid IL-4;Nasal lavage fluid p-JAK1;Nasal lavage fluid p-STAT6;Nasal lavage fluid IgE;Nasal lavage fluid IL-5;Nasal lavage fluid IL-6;Nasal lavage fluid IL-10;Nasal lavage fluid IL-13;Nasal lavage fluid IL-17;Nasal lavage fluid IFN-?;Nasal lavage fluid Eosinophils;Th2 cells after Mel's intervention;IL-4 after Mel's intervention on Th2 cells ;IL-4 mRNA after Mel's intervention on Th2 cells;IL-4 after Mel antagonist's intervention on Th2 cells;p-JAK1 after Mel antagonist's intervention on Th2 cells;p-STAT6 after Mel antagonist's intervention on Th2 cells;IL-4 mRNA after Mel antagonist's intervention on Th2 cells;JAK1 mRNA after Mel antagonist's intervention on Th2 cells;STAT6 mRNA after Mel antagonist's intervention on Th2 cells;JAK1 gene DNA methylation after Mel antagonist's intervention on Th2 cells;STAT6 gene DNA methylation after Mel antagonist's intervention on Th2 cells;HNECs TER;Permeability of HNECs to FD4;HNECs ZO-1;HNECs Occcudin;HNECs Claudin-1;p-JAK1 after IL-4's intervention on HNECs;p-STAT6 after IL-4's intervention on HNECs;JAK1 mRNA after IL-4's intervention on HNECs;STAT6 mRNA after IL-4's intervention on HNECs;JAK1 gene DNA methylation after IL-4's intervention on HNECs;STAT6 gene DNA methylation after IL-4's intervention on HNECs;IL-4 after Mel's intervention on HNECs;p-JAK1 after Mel's intervention on HNECs;p-STAT6 after Mel's intervention on HNECs;IL-4 mRNA after Mel's intervention on HNECs;JAK1 mRNA after Mel's intervention on HNECs;STAT6 mRNA after Mel's intervention on HNECs;JAK1 gene DNA methylation after Mel's intervention on HNECs;STAT6 gene DNA met | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in TNSS scores of patients in four seasons;Changes in VAS scores of patients in four seasons;Changes in NRQLQ scores of patients in four seasons; | — |
Countries
China
Contacts
Public ContactWeiling Yuan
College of TCM, Tianjin University of Traditional Chinese Medicine
Outcome results
None listed