Hepatocellular Carcinoma
Conditions
Interventions
2:ALPPS
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. unresectable HCC diagnosed by clinical, pathological or cytological methods; 2. Criteria of clinical diagnosis: history of liver disease, AFP >= 400ng/mL, classical characteristics of HCC by ultrasound or imaging examination; 3. Imaging examination indicates that lesion(s) is(are) confined within left/right lobe of liver with no limitation of size(s); 3D reconstruction of CT indicates: insufficient ratio of future liver remnant and standardized liver volume (FLR/SLV), that is 18 years old and = 60ml/min; (2) ALT and AST are lower than 2.5 times upper limit of normal respectively, or they could be recovered to this range after treatment; (3) Left ventricular ejection fraction >= 50%; no pericardial effusion; no clinically abnormalities detected by electrocardiogram (ECG). (4) Little or no pleural/peritoneal effusion; oxyhemoglobin saturation (SpO2) >= 95%; 8. Patients who volunteer to participate in this study and sign the informed consent (ICF).
Exclusion criteria
Exclusion criteria: 1. Unable to diagnose HCC; 2. Patients who can tolerate primary resection of tumor with enough liver function and future liver remnant; 3. Child-Pugh score >= 7; ECOG score>= 2; 4. Other factors of patients who cannot tolerate the surgery, such as those who are defined as the intolerable by anesthesiologists after evaluating the function of heart, lung and kidney; 5. HCC patients who have already received other anti-tumor therapies; 6. Patients who are not willingly to participate in this study or cannot participate in the whole process owing to financial or time problems.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor resection rate;objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 3 years' survival;Recurrence-free survival; | — |
Countries
China
Contacts
Public ContactChen Yajin
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed