Acute pain
Conditions
Interventions
Low-dose esketamine group:Patients are given 0.3mg/kg esketamine nasal spray
Moderate-dose esketamine group:Patients are given 0.5mg/kg esketamine nasal spray
Placebo:Patients are given saline nasal spray
Sponsors
Department of Anesthesiology, Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Eligible patients were between 18 and 75 years old; 2. had an American Society of Anesthesiologists (ASA) physical status of I–III; 3. scheduled for elective video-assisted thoracoscopic surgery, and had small lung nodules on preoperative CT-guided localization.
Exclusion criteria
Exclusion criteria: 1. Patients were excluded if they had clinically significant cardiovascular diseases; 2. previous history of pulmonary surgery; 3. patients with severe respiratory pathology; 4. patients with psychiatric disorders (schizophrenia, mania, bipolar abnormalities, psychosis, etc.) and a history of long-term psychotropic drug use and cognitive dysfunction; 5. women who are pregnant or breastfeeding; 6. Chronic pain treated with long-term oral pain medication; 7. unable to perform the visual analogue scale (VAS); 8. had undergone previous thoracic surgeries; 9. had received chronic pain medication; 10. diagnosed with herpes zoster accompanied by debilitating pain; 11. other factors that investigators considered to be inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects; | — |
Countries
China
Contacts
Public ContactYuwei Qiu
Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of medicine, Shanghai, China
Outcome results
None listed