heart disease
Conditions
Interventions
experimental group:Anesthesia with Ciprofol
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. CBP valve replacement and coronary artery bypass grafting under direct vision; 2. Aged >= 18 years; 3. ASA II - ? level; NYHA II- ? level; 4. Ability to participate in neuropsychological tests and interview; 5. Clearly understand, volunteer to participate in the trial and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of neuropsychiatric disorders or personal history of intellectual disabilities or speech and cognitive impairment; 2. Uncontrolled hypertension, diabetes, tumors, or blood history; 3. Long-term use of psychoactive drugs; 4. Preoperative complication was severe hepatic and renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of perioperative neurocognitive disorders; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP change value during general anesthesia;HR change value during general anesthesia;SPO2 change value during general anesthesia;BIS change value during general anesthesia;incidence of low cardiac output after sugery;Urea;creatinine;cystatin C levels;glomerular filtration rate;Urine volume;BUN;TNF-a;IL-1ß;IL-6;IL-10;CRP;Euroscore value;rate of Intraoperative hemodynamic fluctuations;Incidence of AKI;value of QoR-15; Incidence of vomiting after surgery;Incidence of infusion pain;body temperature;Incidence of hyoxenia;Urine volume; | — |
Countries
China
Contacts
Public ContactJing Shi
Department of anesthesiology ,Affiliated Hospital of Guizhou Medical University
Outcome results
None listed