Liver Cancer
Conditions
Interventions
case series:none
Sponsors
The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Hematological, imaging, cytological or pathological confirmation of hepatocellular carcinoma, including hepatocellular carcinoma, cholangiocarcinoma and hepatoblastoma; 3. Current or previous treatment with first- or second-line targeted agents for hepatocellular carcinoma, including sorafenib, lenvatinib, bevacizumab, regorafenib and apatinib; 4. Expected survival >= 6 months; 5. Efficacy evaluation criteria for solid tumours according to RECIST version 1.1, with at least one evaluable lesion; 6. The patient or legal guardian fully understood the FMT treatment process and mechanism and signed the informed consent for treatment and basic information form, and understood and approved this study.
Exclusion criteria
Exclusion criteria: 1. Unstable vital signs (temperature, heart rate, blood pressure, respiration), severe systemic infections, heart, brain, lung and renal impairment and other related diseases, and vancomycin allergy; 2. Large gastrointestinal ulcers, bleeding or propensity to perforate; 3. Intestinal obstruction of various causes; 4. Those with combined severe malnutrition (body mass index < 15 kg/m2) and severe hypoproteinemia (albumin < 25 g/L); 5. Recent post-operative major surgery and during recovery; 6. Contraindications to the transplant operation itself (transoral diet); 7. Allergy to the ingredients and contents of the capsule; 8. Patients in a state of pregnancy or breastfeeding; 9. Patients with poor compliance who do not accept clinical observation; 10. Other conditions which, in the opinion of the investigator, are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease control rate;Overall survival;Progression-free survival;Gut microbes; | — |
Countries
China
Contacts
Public ContactTian Xuefei
Hunan University of Traditional Chinese Medicine
Outcome results
None listed