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Effect of dexmedetomidine on endothelial glycocalyx in patients undergoing cardiac surgery with cardiopulmonary bypass

Effect of dexmedetomidine on endothelial glycocalyx in patients undergoing cardiac surgery with cardiopulmonary bypass

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061672
Enrollment
Unknown
Registered
2022-06-30
Start date
2022-06-30
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

valvular heart disease

Interventions

Dexmedetomidine group :Dexmedetomidine
Normal saline group:Normal saline

Sponsors

the First Affiliated Hospital of Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Sign the informed consent form; 2. Elective cardiopulmonary bypass heart surgery, including heart valve replacement and coronary artery bypass grafting; 3. Aged 18-75 years.

Exclusion criteria

Exclusion criteria: 1. Emergency surgery; 2. Previous cardiac surgery; 3. Infection status or long-term use of anti-inflammatory drugs; 4. Sick sinus syndrome or atrioventricular block; 5. Patients allergic to dexmedetomidine.

Design outcomes

Primary

MeasureTime frame
Syndecan-1;—

Secondary

MeasureTime frame
heparan sulfate;—

Countries

China

Contacts

Public ContactWang Weijian

Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University

359847916@qq.com+86 13806683232

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026