Cervical Cancer
Conditions
Interventions
experimental group:receive modified C1 hysterectomy
control group:receive conventional C2 hysterectomy
Sponsors
National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Pathologically diagnosed as cervical squamous call carcinoma, adenocarcinoma, or adenosquamous carcinoma; 2. Aged 18 - 70 years; 3. Stage IB1, IB2, IIA1 (FIGO 2018); 4. No evidence of distant metastasis in whole body imaging (chest, abdominal, pelvic CT; PET-CT); 5. ECOG <= 2 and able to tolerate hysterectomy and pelvic lymphadenectomy; 6. No serious cardiac, hepatic, renal chronic diseases or dysfunction, or history of other malignant tumors; 7. Volunteer to participate in this study and have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pathologically diagnosed as cervical small cell carcinoma, neuroendocrine carcinoma, or other special types of carcinoma; 2. Preoperative evaluation suggests that the tumor is closely related to pelvic autonomic nerves and unable to reserve nerves; 3. Preoperative urination, defecation, or sexual dysfunction; 4. Accepted radiotherapy or chemotherapy before participating in this study; 5. Serious complications that affect operations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery rate of spontaneous;2-year disease-free survival rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of operation;Intraoperative bleeding volume;Blood transfusion ratio;Operative complications;Hospitalization time;Bladder function;Rectal function;Sex function; | — |
Countries
China
Contacts
Public ContactDan Zhao
National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed