Perioperative neurocognitive dysfunction
Conditions
Interventions
Program controlled paravertebral analgesic group:Preoperative paravertebral catheterization and 20mL injection of 0.5% ropivacaine solution from the catheter, postoperative program-controlled paravert
Intravenous patient controlled analgesia group:Postoperative intravenous patient controlled analgesia
Sponsors
Beijing Chest Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60 - 75 years, no gender limitation; 2. Patients with clear consciousness and good communication; 3. Pulmonary resection with VATS was performed.
Exclusion criteria
Exclusion criteria: 1. Refused or failed to complete preoperative cognitive function tests; 2. Dementia, or central nervous system diseases that may lead to dementia, such as cerebrovascular disease, Parkinson's disease, encephalitis, epilepsy, brain tumors, brain trauma, etc.; 3. MMSE score < 24; 4. preoperative hearing or vision impairment, communication difficulties; 5. Serious sleep disorders, long-term use of sedatives, antidepressants or alcohol; 6. Patients with persistent chronic pain or long-term oral opioid analgesics before surgery; 7. Patients undergoing thoracotomy or serious surgical complications requiring a second operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delayed early cognitive recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| number rating score;The Montreal Cognitive Assessment Scores;Montreal Cognitive assessment scores (telephone type);Mean arterial pressure;Total opioid consumption within (including analgesic pump dosage and analgesic relief opioid dosage);Postoperative delirium;postoperative nausea and vomiting;Postoperative chronic pain;Neurofilament light protein;tau protein;IL-6;tumor necrosis factor-a;C-Reactive Protein;Duration of chest tube indwelling;analgesic remedy;15-item recovery quality rating scale score;Neuropathic pain Scale; | — |
Countries
China
Contacts
Public ContactLiu Wei
Beijing Tuberculosis and Thoracic Tumor Research Institute
Outcome results
None listed