Postoperative heart rate changes in elderly patients with general anesthesia
Conditions
Interventions
Test group:Glycopyrrolate-neostigmine
Control group:Atropine-neostigmine
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective general anesthesia for non-cardiac surgery; 2. The expected operation time <4 hours; 3. Neostigmine was used to antagonize neuromuscular blockade after surgery; 4. Aged 65-80, male or female; 5. American Society of Anesthesiologists (ASA) Grade I-II; 6. 18kg/m2<= Body mass index (BMI) <=28kg/m2; 7. Patients who volunteered to participate in this trial and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to anticholinergic drugs and their components; 2. Patients with respiratory, circulatory, and digestive system diseases that affect heart rate; 3. Patients with abnormal liver and kidney function; 4. Patients who are using drugs that affect the cholinergic system; 5. Dementia or Mini-Mental State Examination (MMSE) score < 24; 6. Poor communication skills.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate (HR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate change;Mean arterial pressure (MAP);ST-II;Emergence agitation (EA);Postoperative delirium (POD);Atropine remedial treatment;Dry mouth;Nausea;Vomiting;Cardiovascular complications;Exhaust time; | — |
Countries
China
Contacts
Public ContactWang Yanping
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed