Depression
Conditions
Interventions
ESK group:During the induction of intoxication, S(+)-ketamine 0.5 mg/kg (diluted to 5 ml with normal saline) was given after the patient lost consciousness, and S(+)-ketamine 0.25 mg/kg/h (diluted wit
NS group:During anesthesia induction, 5ml of normal saline was given after the patient's consciousness disappeared, and 0.25ml/kg/h of normal saline was given during the anesthesia maintenance phase.
Sponsors
Ethics Committee of Hangzhou First People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who received modified radical mastectomy for unilateral breast cancer; 2. Age 18-65 years old; 3. American Society of Anesthesiologists (ASA) Physical Condition Class I-II; 4. Body mass index (BMI) 18-40 kg/m2; 5. Fully informed consent and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with other mental illnesses such as schizophrenia, mania, or a history of mental illness; 2. Patients who have received psychotropic medication; 3. Uncontrolled high blood pressure, elevated intraocular pressure; 4. Patients with other serious systemic diseases (including severe heart, kidney and liver disease); 5. Allergic to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton-17 Rating Scale (HAMD-17) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Venous blood;Serum 5-HT level;Changes of heart rate and blood pressure before and after intubation;Heart rate and blood pressure changes every 5 minutes during anesthesia maintenance;Recovery time;VAS pain score 30min after extubation;VAS pain score 24h after surgery; | — |
Countries
China
Contacts
Public ContactXinlei Lu
Hangzhou First People's Hospital
Outcome results
None listed