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The impact of different odors during heel lance procedure on pain, stress and early neural development in preterm infants: A randomized controlled trial

The impact of different odors during heel lance procedure on pain, stress and early neural development in preterm infants: A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061572
Enrollment
Unknown
Registered
2022-06-29
Start date
2022-06-15
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature

Interventions

Group 1:Maternal breast milk olfactory stimulation
Group 2:Donor breast milk olfactory stimulation
Group 3:Distilled water olfactory irritation

Sponsors

Shanghai Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Premature; 2. SpO2 >88%, heart rate 120-160/min, Respiratory rate of 40 to 60 beats per minute; 3. No congenital diseases or genetic abnormalities; 4. 5 minutes after birth Apgar score > 7 points; 5. Receiving breastfeeding; 6. Informed consent and voluntary participation in this study.

Exclusion criteria

Exclusion criteria: 1. With olfactory impairment; 2. Use antidepressants and anticonvulsants, muscle relaxants, sedative and analgesics and anesthetic drugs within 48 hours; 3. Neonatal asphyxia after resuscitation.

Design outcomes

Primary

MeasureTime frame
Score of pain level;—

Secondary

MeasureTime frame
Salivary cortisol;Neonatal Behavioral Neurological Assessment;—

Countries

China

Contacts

Public ContactJiang Yan

Shanghai Children's Hospital

jy122014@163.com+86 15026685979

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026