Atherosclerosis
Conditions
Interventions
Observation group:None
Sponsors
The Fifth Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Experimental group (Advanced AS): (1) 45-65 years old; (2) Patients with extracranial carotid artery plaque and carotid intima thickness >1.2mm confirmed by dual-power ultrasound examination, and able to cooperate with biological specimen sampling; (3) Informed consent was voluntarily signed before the study, and patients and/or their legal representatives were able to fully understand possible adverse reactions during the sampling process. 2. Control group (early AS): (1) 45-65 years old; (2) Patients with no plaque or stenosis in extracranial carotid artery confirmed by dual-power ultrasound, carotid intima thickness < 1.2mm, and compatible with biological specimen sampling; (3) Informed consent was voluntarily signed before the study, and patients and/or their legal representatives were able to fully understand possible adverse reactions during the sampling process.
Exclusion criteria
Exclusion criteria: 1. Patients with extracranial carotid artery dissection, extracranial carotid artery fibromuscular dysplasia, and extracranial carotid artery physiological and anatomical abnormalities; 2. Persons suffering from psychological, psychiatric, or neurological diseases; 3. Complicated with coagulopathy, active bleeding, severe infection with poor clinical control, etc.; 4. Patients who also participated in another clinical study; 5. Those who cannot cooperate with biological specimen collection; 6. Other participants judged by the investigator to be unsuitable for the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of marker genes; | — |
Countries
China
Contacts
Public ContactQunying Zhang
The Fifth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed