Sperm DNA damage in male infertility
Conditions
Interventions
Treatment group:Oral Wuwei Fuzheng Yijing formula
Control group:Oral levocarnitine oral solution
Sponsors
No.1 Affiliated Hospital of Henan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Male, aged from 22 to 45 years old; 2. Diagnosed as sperm DNA damage in male infertility; 3. In accordance with the syndrome differentiation standard of spleen and kidney qi deficiency and blood stasis syndrome in traditional Chinese medicine; 4. Normal sexual life and regular sexual life (the frequency of sexual life is required to be no less than once per week); 5. The informed consent of the patient and the voluntary signing of the informed agreement by the patient, which meets the basic requirements of the ethics committee.
Exclusion criteria
Exclusion criteria: 1. Infertility caused by organic lesions of the reproductive system or female infertility; 2. Infertility caused by inability to complete sexual intercourse, including, but not limited to, erectile dysfunction and ejaculation disorders; 3. Genitourinary tract obstruction and infection, such as chlamydia trachomatis or mycoplasma infection; 4. Chromosomal abnormalities (including karyotypic abnormalities and Y chromosome microdeletions); 5. Patients with a history of drug allergy or allergy; 6. With abnormal sex hormone and seminal plasma biochemical examination; 7. With primary diseases such as severe cardiovascular, liver, kidney, and hematopoietic system and unable to cooperate with treatment; 8. Using drugs affecting experimental research within 3 months; 9. Participated in other clinical trials in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm DNA fragmentation rate;Sperm motility;Sperm survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sperm concentration; | — |
Countries
China
Contacts
Public ContactWang Zulong
Henan University of Traditional Chinese Medicine (Dongming Road Campus)
Outcome results
None listed