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Effectiveness and safety evaluation of repetitive transcranial magnetic stimulation therapy combined with mindfulness-based stress reduction for people with post-stroke depression: a double-blinded randomized controlled trial

Clinical application study of repetitive transcranial magnetic stimulation combined with mindfulness-based stress reduction for people with post-stroke depression

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061523
Enrollment
Unknown
Registered
2022-06-27
Start date
2022-06-20
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posr-stroke depression

Interventions

rTMS group:HF-rTMS therapy
MBSR group:MBSR program
Combined treatment group:HF-rTMS combined with MBSR program

Sponsors

First Hospital of Shanxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
28 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Report a confirmed diagnosis of ischemic PSD; 2. Age 25-75 years old; 3. Clear consciousness, stable condition, normal intelligence, no communication impairment; 4. HADM-17>=8; 5. Have good compliance; 6. If receiving stroke treatment, the treatment regimen was stable, the dose of medication was stable in the last month, and there was no plan to increase the dose; 7. If taking antidepressants, the dose was stable for more than 8 weeks.

Exclusion criteria

Exclusion criteria: 1. Clear presence of intracranial hemorrhagic lesions on imaging; 2. Diagnosis of other psychiatric disorders; 3. Previous history of depression or psychosis; 4. Patients with major depression with HAMD >=24; 5. Metal implants in the body; 6. Suicidal ideation; 7. Aphasia or severe cognitive impairment, or severe language comprehension deficits due to other causes; 8. Other brain diseases such as Parkinsons, encephalitis, epilepsy, multiple sclerosis, head injury, etc.; 9. Undergoing other psychological treatment.

Design outcomes

Primary

MeasureTime frame
Depression state;

Secondary

MeasureTime frame
Neurological function;Cognitive function evaluation;Activities of daily living;Global quality of life;

Countries

China

Contacts

Public ContactYan Xin

First Hospital of Shanxi Medical University

xinyan6712@sina.com+86 13834159131

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026