Procedural pain caused by subcutaneous injection of recombinant human granulocyte colony-stimulating factor in patients with hematological malignancies
Conditions
Interventions
N2O/O2 mixture group:N2O/O2
O2 group:O2
Sponsors
Shenzhen University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 and above; 2. rhG-CSF has no pain before H; 3. The patient was conscious and able to correctly understand and use Numeric Rating Scale (NRS) to express the degree of pain; 4. The patient was diagnosed as HM and rhG-CSF with 4 points of H operating pain (NRS); 5. The condition permits monitoring of vital signs; 6. Participate voluntarily and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient suffers from intestinal obstruction; Air embolization; Pneumothorax; Lung cancer; Pneumoencephalography; Epilepsy; Upper respiratory tract infection (cold, bronchitis); Airway obstructive diseases (allergies, nasal polyps, sinusitis); Chronic obstructive respiratory diseases (emphysema, chronic bronchitis, asthma); Diseases of the ear, nose and throat (sinusitis, middle ear disease, tympanic membrane transplantation); Intending to become pregnant or in the stage of pregnancy; Vitamin B12 or folic acid deficiency, immunosuppression; Coma, pneumoencephalography, or diving in the last 1 week; Diving sickness; Severe drug dependence and psychiatric disorders such as schizophrenia and claustrophobic delusions; 2. Patients in critical condition; 3. History of nitrous oxide allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of anxiety;Fear of pain;Satisfaction with pain relief;Acceptance of the analgesic method;BP, P, SpO2;Adverse effects; | — |
Countries
China
Contacts
Public ContactJun-Jun Zhang
Shenzhen University General Hospital
Outcome results
None listed