Helicobacter pylori infection
Conditions
Interventions
Amoxicillin+clarithromycin bismuth quadruple therapy group:None
Empirical treatment group:Amoxicillin+clarithromycin bismuth quadruple therapy
conventional resistance gene in 23S rRNA guided group:Quadruple therapy with bismuth selected under the guidance of conventional resistance gene in 23S rRNA gene mutation detection
clarithromycin resistance gene combination pattern guided group:Quadruple therapy with bismuth selected under the guidance of clarithromycin resistance gene combination detection
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 years; 2. H. pylori infection was confirmed by 13C urea breath test, H. pylori antigen detection in feces, rapid urease test or histological staining before inclusion and was not treated; 3. Agree to undergo gastroscopy according to clinical treatment needs; 4. Informed consent for inclusion in the study.
Exclusion criteria
Exclusion criteria: 1. Penicillin allergy; 2. Acid suppressant drugs and hormones were taken within two weeks, and bismuth agents and antibiotics were taken within one month; 3. Pregnant or lactating patients; 4. Patients with serious diseases, such as severe liver disease, heart disease, kidney disease, alcoholism, malignant tumor, etc.; 5. Mental illness, severe neurocognitive impairment and inability to partner.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum inhibitory concentration;Combination patterns of clarithromycin resistance genes; | — |
Countries
China
Contacts
Public ContactLuo Qingfeng
Beijing Hospital
Outcome results
None listed