None listed
Conditions
Interventions
Group A1:The depth of anesthesia (BIS) was 35, and the remifentanil effect chamber concentration (CeREMI) was 2 ng/ml
Group A2:The depth of anesthesia (BIS) was 35, and the remifentanil effect chamber concentration (CeREMI) was 4 ng/ml
Group A3:The depth of anesthesia (BIS) was 35, and the remifentanil effect chamber concentration (CeREMI) was 6 ng/ml
Group B1:The depth of anesthesia (BIS) was 65, and the remifentanil effect chamber concentration (CeREMI) was 2 ng/ml
Group B2:The depth of anesthesia (BIS) was 65, and the remifentanil effect chamber concentration (CeREMI) was 4 ng/ml
Group B3:The depth of anesthesia (BIS) was 65, and the remifentanil effect chamber concentration (CeREMI) was 6 ng/ml
Sponsors
Honghui Hospital Affiliated to Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 60-75 years who underwent elective total knee replacement; 2. American Society of Anesthesiologists (ASA) grade I to III; 3. General anesthesia is required.
Exclusion criteria
Exclusion criteria: 1. Inability to communicate before surgery due to coma, severe dementia, speech impediment or serious disease; 2. Severe chronic obstructive pulmonary disease or congestive heart failure; 3. Use of sedative/analgesic/psychoactive drugs (including alcohol) within seven days prior to admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of oxygenated hemoglobin in the cerebral cortex; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of cerebral cortex deoxyhemoglobin;Concentration of total hemoglobin in the cerebral cortex; | — |
Countries
China
Contacts
Public ContactLi Jing
Honghui Hospital Affiliated to Xi'an Jiaotong University
Outcome results
None listed