Effects of preoperative stress level on bone endocrine in elderly patients with hip fracture and its role in postoperative delirium

Effects of prehospital regional block analgesia on bone endocrine in elderly patients with hip fracture and its role in postoperative delirium

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200061407

Enrollment

Unknown

Registered

2022-06-23

Start date

2022-06-10

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium (POD)

Interventions

Exposed group:None

Non-exposed group:None

Eligibility

Sex/Gender

All

Age

65 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. The confirmed hip fracture site is only unilateral; 2. Aged >=65 years; 3. ASA classification ?, ?, III; 4. No history of allergy to narcotic drugs; 5. Consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Patients with pain score 1.4, platelet <80x10^9); 3. Pathological fracture; 4. Metabolic bone disease; 5. Old fracture; 6. History of stroke within 6 months before surgery; 7. Patients with dementia, mental illness and preoperative delirium; 8. Patients dependent on alcohol or drugs; 9. Aphasia and hearing impairment; 10. Patients with Parkinson's disease.

Design outcomes

Primary

Measure	Time frame
Osteocalcin;	—

Secondary

Measure	Time frame
Lipocalin-2;Osteopontin;Osteoprotegerin;Cortisol;Epinephrine;Norepinephrine;Inflammatory factor;Blood pressure;Heart rate;	—

Countries

China

Contacts

Public ContactWang Geng

Beijing Jishuitan Hospital

w_geng@163.com+86 13910676672

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026