Stroke
Conditions
Interventions
Intervention group:The patient's healthy upper limb was adapted to remote ischemia of 200mmhg, inflated for 5 minutes, deflated for 5 minutes as a cycle, and a total of 4 cycles were completed
Control group:The patient's healthy upper limb was isolated from ischemia and adapted to 0mmhg. The patient was bound for 40 minutes and simulated to complete 4 cycles
Sponsors
Beijing Emergency Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adults aged over 18 years; 2. Suspected acute stroke was judged by the pre-hospital doctor; 3. From the onset of stroke symptoms (the patient's last normal time) to the randomization time of ambulance physicians within 12 hours; 4. Prehospital great vessel occlusion score G-FAST>=3 points; 5. Informed consent signed by the patient himself or his family.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications for intravascular interventional therapy (such as contrast media, peripheral artery occlusion, etc.) and unable to perform mechanical thrombectomy; 2. mRS (modified Rankin scale score) >2 before the onset of the stroke; 3. Patients with the previous responsible side cerebral artery occlusion; 4. History suggests apoplexy due to arterial dissection; 5. Dementia patients; 6. Patients who are breastfeeding or pregnant; 7. Severe renal insufficiency requiring dialysis or creatinine clearance < 29 mL/min; 8. Patients with severe systemic diseases and expected survival time of no more than 3 months; 9. Contraindications of distal ischemia adaptation: known upper limb peripheral vascular diseases such as severe soft tissue injury, fracture and sensory disturbance; 10. The researcher believed that the patient had other conditions that could not be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infarct size 7 days after onset of acute ischemic stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with good neurological function (modified Rankin scale, mRS, 0-2 points) 90 days after onset;Distribution of mRS at 90 days after onset;G-FAST score during pre hospital reception and after arrival and before handover;National Institutes of Health Stroke Scale (NIHSS) score on the 7th day of admission;90 day all-cause mortality; | — |
Countries
China
Contacts
Public ContactLi Dou
Outcome results
None listed