Diseases with indications for total hip arthroplasty
Conditions
Interventions
control group:traditional total hip arthroplasty
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 ~ 80 years old, regardless of gender; 2.Patients who meet the requirements of total hip arthroplasty and need the primary total hip arthroplasty according to the evaluation of the researchers; 3.The subjects fully understand the benefits and risks of this trial and are willing to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with neuromuscular dysfunction (e.g. paralysis, myolysis or abductor weakness) that can lead to postoperative hip instability or abnormal gait; 2.Active infection lesions in the hip joint or other parts of the body; 3.Patients with severe hip deformity and hip dysplasia with Crowe grade 3 or 4; 4. Ankylosing spondylitis patients with bony ankylosis or severe stiffness; 5. Patients with bilateral hip arthroplasty at the same time, or patients with contralateral hip arthroplasty within 3 months, or patients with contralateral hip arthroplasty expected to be performed within 1 year after operation; 6. The patient is known to have a history of allergy to one or more implanted materials; 7. Patients with severe internal and surgical diseases or weak physiques and unable to tolerate surgery; 8. Patients with poor expected compliance; 9. Pregnant or lactating women, or patients with family planning during clinical research; 10. The patient participating in other drug clinical trials within 3 months before enrollment, or other device clinical trials within 1 month before enrollment; 11.Patients with insulin resistance caused by diabetes or drugs; 12. Other circumstances that the researchers consider inappropriate for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin resistance index(HOMA-IR(HOMA-IR 1 day after surgery ); | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose (one day before and after operation);Fasting insulin (one day before and after operation);Islet of Langerhans ß Cellular function;Insulin sensitivity index;CRP (within 7 days before operation, 6 hours after operation, 1 day after operation, 3 days after operation, 21 days after operation);ESR (within 7 days before operation, 6 hours after operation, 1 day after operation, 3 days after operation, 21 days after operation);IL-6 (within 7 days before operation, 6h after operation, 1 day after operation, 3 days after operation and 21 days after operation);Cortisol (within 7 days before operation, 6 hours after operation, 1 day after operation, 3 days after operation and 21 days after operation);Serum amyloid A (within 7 days before operation, 6 hours after operation, 1 day after operation, 3 days after operation and 21 days after operation);Active hip flexion angle (within 7 days before operation, 3 days after operation and 21 days after operation);Active hip abduction angle (within 7 days before operation, 3 days after operation and 21 days after operation);Straight leg raising time (within 7 days before operation, 3 days after operation and 21 days after operation);VAS score (within 7 days before operation, 1 day after operation, 2 days after operation, 3 days after operation, 21 days after operation);Intraoperative bleeding;Postoperative drainage;Total postoperative bleeding; | — |
Countries
China
Contacts
Public ContactZongke Zhou
Outcome results
None listed