lung cancer
Conditions
Interventions
case series:NA
Sponsors
Fujian Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Non-small cell lung cancer diagnosed by histopathology or cytology; molecular pathology (tissue, ARMS method or NGS) negative for EGFR and ALK (genetic testing may not be performed in patients with squamous lung cancer); stage IV diagnosis confirmed by imaging; no prior antitumor therapy; intolerance to standard-dose chemotherapy as determined by the investigator: 1) age > 75 years; 2) ECOG score >= 2; 3) Those with comorbid underlying disease not amenable to platinum-containing two-drug chemotherapy; measurable or evaluable lesions according to RECIST 1.1 criteria; patients were fully informed of this study and voluntarily signed a written informed consent; expected survival > 3 months.
Exclusion criteria
Exclusion criteria: Tumor histology or cytologic pathology confirmed combined small cell lung cancer component; patients with cranial metastases with neurological or psychiatric symptoms; patients with asymptomatic brain metastases could be enrolled; those with oral drug impairment; and other conditions that the investigator considered not eligible for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| objective response rate;disease control rate; | — |
Countries
China
Contacts
Public ContactZhiyong He
Outcome results
None listed