Postoperative acute pain and early cognitive dysfunction
Conditions
Interventions
Experimental group:esketamine
Control group:sufentanil
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who plan to undergo laparoscopic gastrointestinal surgery and are >= 60 years old, and the type of surgery includes laparoscopic radical resection of gastric cancer, colon cancer, and rectal cancer; American Society of Anesthesiologists (ASA) classification I-III; 2. Agree to postoperative intravenous patient-controlled analgesia; 3. BMI 18-25 kg/m2; 4. Voluntarily participate in the research and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of chronic pain; 2. History of opioid or alcohol abuse; 3. The preoperative visit found that the MMSE score of illiteracy < 17 points, primary school < 20 points, and junior high school and above < 24 points; 4. Nervous system diseases; 5. Patients with poorly controlled or untreated hypertension (resting systolic blood pressure/diastolic blood pressure exceeding 180/100 mmHg); 6. Increased intraocular pressure (glaucoma), increased intracranial pressure; 7. Patients with untreated or undertreated hyperthyroidism; 8. Severe cardiopulmonary dysfunction; 9. Severe visual impairment; 10. Lack of cooperation or communication skills; 11. Hypersensitivity to the active ingredients of esketamine or all excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain score;patient controlled intravenous analgesia (PCIA) press number;Postoperative recovery quality assessment scale of 15 items; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delirium 3 days after surgery;self-rating anxiety scale;Self-rating Depression Scale;Athens Insomnia Scale;postoperative complications; | — |
Countries
China
Contacts
Public ContactJiang Peng
Affiliated Hospital of Jiangsu University
Outcome results
None listed