postoperative neurocognitive impairment
Conditions
Interventions
Experimental group:Probiotics+vitb6 injection+0.9% sodium chloride injection
Control group:Placebo capsule+0.9% sodium chloride injection
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Elective hip/knee replacement patients; 2. Aged 60-80 years old, gender is not limited, race is not limited; 3. Expected hospital stay >= 7 days; 4. No immune system disease; 5. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Participating in other clinical trials; 2. The patient underwent multiple (more than one) operations or emergency operations during this hospitalization due to the needs of the patient's condition; 3. Suffering from Parkinson's disease or other neurological diseases that cause dysfunction; 4. Unable to communicate due to coma, severe dementia, language barrier, severe auditory or visual impairment, terminal disease, etc. before operation; 5. Critical condition (preoperative ASA grade >= IV); 6. Have used antibiotics, probiotics, and gastrointestinal motility drugs within 10 days before admission; 7. Severe renal impairment (requiring renal replacement therapy); 8. Severe liver damage (Child-Pugh grade C); 9. The attending doctor or researcher believes that there are other conditions that are not suitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delirium;Cognitive ability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood inflammation level; | — |
Countries
China
Contacts
Public ContactJiangbin Tong
The Third Xiangya Hospital of Central South University
Outcome results
None listed