Effects of zero equilibrium ultrafiltration on perioperative neurocognitive dysfunction (PND) in patients undergoing cardiac surgery under cardiopulmonary bypass

Application and prevention of balanced ultrafiltration in perioperative neurocognitive dysfunction in patients undergoing cardiac surgery under cardiopulmonary bypass

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200061269

Enrollment

Unknown

Registered

2022-06-18

Start date

2022-07-01

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart surgery

Interventions

Group 1:Conventional ultrafiltration is performed during cardiopulmonary bypass

Group 2:Zero equilibrium ultrafiltration in cardiopulmonary bypass

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. CBP valve replacement and coronary artery bypass grafting under direct vision; 2. Age > 18 years old; 3. ASA II-IV; 4. NYHAII/III level.

Exclusion criteria

Exclusion criteria: 1. People with a history of neurological and mental diseases, such as dementia, language barriers, etc.; 2. Use of ECMO during or after surgery for any reason; 3. Patients who request to quit halfway, have incomplete data or are lost to follow-up; 4. Those who need secondary surgery in the hospital; 5. Patients with severe hemodynamic disturbance or malignant arrhythmia during operation; 6. Postoperative adverse events, such as severe allergic reactions, death, etc.

Design outcomes

Primary

Measure	Time frame
Perioperative neurocognitive dysfunction;	—

Countries

China

Contacts

Public ContactXinglong Xiong

Affiliated Hospital of Guizhou Medical University

luxxl@qq.com+86 15085992699

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026