autoimmune diseases
Conditions
Interventions
Group 1 :CAR-T cells
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
5 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Chinese subjects aged >= 5 years old and 12 weeks; 3. The autoimmune disease is diagnosed by physical examination, pathological examination, laboratory examination and imaging, and the effect of conventional treatment is not good, and there is no effective treatment; 4. Creatinine < 2.5 mg/dl; 5. ALT, AST < 3 times ULN; 6. Bilirubin < 2.0 mg/dl; 7. ECOG score 0-1; 8. The peripheral superficial venous blood flow of the patient is smooth, which can meet the needs of intravenous infusion; 9. Subjects/legal guardians must obtain and sign an informed consent form, indicating that they understand the purpose and procedures of this study and are willing to participate in the study; they are willing and able to follow the contraindications and restrictions specified in this protocol.
Exclusion criteria
Exclusion criteria: 1. Women who are pregnant (positive blood pregnancy test) or breastfeeding, or women who have a pregnancy plan within one year; 2. Infectious diseases (such as HIV, active hepatitis B or C infection, active tuberculosis, etc.); 3. Patients have participated in other clinical trials before enrollment and have not passed the washout period; 4. The vital signs are abnormal, and those who cannot cooperate with the examination; 5. Highly allergic constitution or history of severe allergies, especially those allergic to IL-2; 6. Suffering from serious mental illness; 7. The patient has drug abuse/addiction; 8. Subjects with systemic infection or local severe infection requiring anti-infection treatment; 9. Combined with dysfunction of heart, lung, brain, liver, kidney and other important organs; 10. According to the investigator's judgment, the patient has other conditions that are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety;Efficacy;Progression Free Survival; | — |
Countries
China
Contacts
Public ContactCao Jiang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed