Osteoarthritis, femoral head necrosis
Conditions
Interventions
NONFH conforms to the Guidelines for the Clinical Diagnosis and treatment of Adult femoral head necrosis in China (2020).
Index test:Apolipoprotein 
A-IV, 
apolipoprotein 
serum 
leucocyte 
(LECT2), 
I 
converting 
enzyme 
(ACE), 
inducer 
Sponsors
Linyi People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with osteoarthritis are included as follows: (1) Patients diagnosed with knee osteoarthritis; (2) The patient is over 18 years old, and liver and kidney diseases, malignant tumors and other systemic diseases are excluded; (3) Exclude joint diseases such as rheumatism and rheumatoid; (4) No history of joint drug injection, painkiller drug use, or glucocorticoid drug use within 3 months before blood drawing; 2. Patients with non-traumatic femoral head necrosis include the following persons: (1) NONFH complies with the Guidelines for Clinical Diagnosis and Treatment of Adult Necrosis of the Femoral Head in China (2020); (2) Association Research Circulation Osseous (ARCO) Phase I-IV; (3) Age > 18 years old; (4) Alcoholic ONFH, with a weekly ethanol intake > 400 ml for more than 6 months and diagnosed within 1 year; (5) Hormonal ONFH, taking prednisolone > 2 g or medication cycle for more than 3 months, and diagnosed within 2 years; (6) Idiopathic ONFH without other obvious predisposing factors; (7) Single factor causes disease.
Exclusion criteria
Exclusion criteria: 1. Those who have suffered from serious basic diseases in the past that affect the accuracy of experimental data and cognitive dysfunction; 2. Suffering from metabolic bone disease or taking drugs that affect bone metabolism recently; 3. Repeated inclusion of case data or incomplete information; 4. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apoprotein D;Apolipoprotein A-IV, ApoA-?;Human cryptothermal protein, NLRP3;White blood cell derivation, LECT2;Angiotensin converting enzyme, ACE;Hypoxia-inducible factor-1, HIF-1a; | — |
Countries
China
Contacts
Public ContactBiaofang Wei
Linyi People's Hospital
Outcome results
None listed