colorectal surgery patients
Conditions
Interventions
Control group:Propofol
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Obtain informed consent; 2. Age >= 60 years old, <= 90 years old; 3. Patients undergoing elective colorectal surgery under general anesthesia; 4. American Society of Anesthesiologists (ASA) classification II-III.
Exclusion criteria
Exclusion criteria: 1. Severe heart, lung, liver and kidney dysfunction; 2. Have a history of mental illness or long-term psychotropic drugs (dementia, schizophrenia), history of taking chronic analgesic drugs, and history of alcoholism; 3. Preoperative Mini-Mental State Examination (MMSE) < 21 points, diagnosed as moderate to severe cognitive impairment; 4. Any cerebrovascular accident occurred within 3 months, such as stroke, transient ischemic attack (TIA), etc.; 5. Patients with severe infection; 6. Preoperative PaO2 < 60 mmHg or SpO2 < 92%; 7. Participated in another drug clinical study within the past 30 days; 8. Hypersensitivity to the test drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POD at 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index;15-item Recovery Quality Rating Scale, QoR-15;Postoperative rest and movement NRS scores;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactSheng Wang
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed