Analgesic effect and safety of nitrous oxide during the manual therapy: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200061175

Enrollment

Unknown

Registered

2022-06-15

Start date

2022-06-01

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rehabilitation training

Interventions

Nitrous oxide group:Inhale nitrous oxide / oxygen mixture

Placebo group:Inhale oxygen

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Patients underwent primary unilateral ligament reconstruction 1. 18-55 years old; 2. Informed and willing to participate in the study; 3. Without any postoperative complication; 4. Recent worst pain (during functional exercise) reported to be 4 or higher (on a Visual Analogue Scale (VAS) of 0 to 10).

Exclusion criteria

Exclusion criteria: 1. Contraindications to the inhalation of the mixture (hemodynamic instability, vitamin B12 deficiency, intracranial hypertension, pneumothorax, intestinal obstruction, epilepsy, pulmonary embolism or facial fractures).

Design outcomes

Primary

Measure	Time frame
Pain score;	—

Secondary

Measure	Time frame
Physiological parameters;Satisfaction;Side effects;	—

Countries

China

Contacts

Public ContactLu Tang

The 960th Hospital of PLA

tanglu_office@163.com+86 15064003655

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 9, 2026