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miRNAs regulate key gene targets of non-syndromic cleft palate-only and determine the phenotype of human cleft palate

MicroRNA-497-5p regulates the key gene targets of cleft lip/palate to determine the phenotype of human cleft lip/palate

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200061150
Enrollment
Unknown
Registered
2022-06-15
Start date
2022-06-01
Completion date
Unknown
Last updated
2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-syndromic cleft palate-only

Interventions

Ipsilateral tissue of non-syndromic cleft palate-only:no
normal palate tissue:no
Mouse cleft palate embryonic palate tissue:no
Mouse normal embryonic palate tissue:no

Sponsors

School of Stomatology Lanzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
0.5 Years to 20 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for normal palate tissue sampling: (1) The patient has no cleft lip and palate, no oral cancer tumors, etc., and the palate tissue is healthy. If it is a trauma patient, the tissue should be removed after debridement; (2) The patient's age is <= 20 years old; (3) The sampling does not affect the later repair; (4) The patient and their families gave informed consent and passed the hospital ethics review. Inclusion criteria for sampling of patients with cleft palate: (1) The patient has only non-syndromic cleft palate-only and no other diseases such as oral cancer; (2) The age of the patient is 6-60 months; (3) The sampling does not affect the later repair; (4) Informed consent of the patient and his family, passed the hospital ethics review.

Exclusion criteria

Exclusion criteria: The exclusion criteria for normal palate tissue sampling: ? The patient suffered from cleft lip and palate, oral cancer tumors and other diseases, and the palate tissue was unhealthy; ? The age of the patient was more than 20 years old; ? The sampling affected the later repair; ? The patient and his family did not give informed consent. Sampling exclusion criteria for patients with cleft palate: ? The patients did not suffer from non-syndromic cleft palate, or oral cancer and other diseases; ? The age of the patients was more than 60 months; ? The sampling affected the later repair; ? The patients and their families did not give informed consent.

Design outcomes

Primary

MeasureTime frame
Molecular level;gene level;—

Countries

China

Contacts

Public ContactZhang Baoping

School/Hospital of Stomatology Lanzhou University

zhangbp@lzu.edu.cn+86 18119448771

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026