Painless gastroenteroscopy
Conditions
Interventions
Test Group:ciprofol injection
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old, no gender limitation; 2. American Anesthesiologist Classification (ASA) I-II; 3. Patients who are scheduled for painless gastroscopy and/or colonoscopy; 4. Body mass index(BMI)>= 18 and = 10 and = 95% when breathing air; systolic blood pressure (SBP) >= 90mmHg and = 60mmHg and = 55 and <= 100 beats/min; 6. Be able to understand the research process and methods, and volunteer to participate in this research.
Exclusion criteria
Exclusion criteria: 1. Those who have contraindications to general anesthesia or those who have had a history of anesthesia accident; 2. Known or suspected propofol injection, cyclopofol injection excipients, benzodiazepines, opioids 3. Patients with acute upper respiratory tract infection, asthma attack or acute severe laryngeal disease; 4. History of gastrointestinal diseases: gastrointestinal retention, active bleeding, Reflux, aspiration, etc.; 5. Complicated with craniocerebral loss, intracranial hypertension, stroke, cerebrovascular accident history, etc.; 6. Respiratory insufficiency, obstructive pulmonary disease, difficult airway, or trachea Difficulty in intubation (modified Martens score grade III or IV); 7. Uncontrolled hypertension, hypotension and diabetes; 8. Severe arrhythmia, heart failure, unstable angina, myocardial infarction, etc.; 9. Severe liver dysfunction or severe renal insufficiency; 10. History of alcoholism or drug dependence; 11. Abuse or long-term use of narcotic, sedative, and analgesic drugs; 12. Those with a history of mental illness; 13. Those who have participated in any drug clinical trial within 1 month before screening; 14. regnant and lactating women; women or men with fertility who are unwilling to use contraception throughout the trial period; those who have a pregnancy plan within 1 month after the trial; Subjects (including male subjects); 15. Subjects who are considered by the investigator to have any other factors that are not suitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroscopy and colonoscopy success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| successful duration of anesthesia induction;insertion time;Lens insertion success rate;Duration of gastroscopy/colonoscopy;Fully awake time (time from pulling out the gastroscope/colonoscope to MOAA/S=5);Time of leaving the room (time from removal of gastroscope/colonoscope to Aldrete score =9);Use of study medicines and alternative medicines (including frequency and dose of medicines, etc.);Physician sedation/anesthesia satisfaction evaluation; | — |
Countries
China
Contacts
Public ContactYunqi Lv
Outcome results
None listed