diabetes and lower extremity arteriosclerosis obliterans
Conditions
Interventions
Sponsors
Beijing hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years; 2. Patients with type 2 diabetes (meeting the diagnostic criteria of the World Health Organization in 1999); 3. Clinical diagnosis of lower extremity arteriosclerosis obliterans, and the symptoms are not completely relieved by routine drug treatment (includes one of the following three situations, and the medication time >= 12 weeks: cilostazol 100 mg per time, twice a day; or salgrelide 100mg per time, three times a day; or beprostaglandin 40 ug per time, three times a day); 4. Meet one of the following standards: ABI = 50% in lower extremity artery by ultrasound, CT or MRI.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney diseases; 2. Acute coronary syndrome and severe cardiac insufficiency; 3. Diabetic ketosis, ketoacidosis; 4. Acute infection; 5. Cancer patients; 6. Resting pain, foot gangrene and inability to walk; 7. Continuous blood pressure >= 160/100 mmhg; 8. Patients with bleeding related history such as gastrointestinal bleeding and retinal bleeding; 9. Patients unable to complete the study for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain-free walking distance;Maximum walking distance;Ankle brachial index;Visual analogue scale;Paresthesia score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor necrosi factora;Interleukin-1;Interleukin-6;Matrix metalloproteinase 9;D-Dimer;High sensitivity C-reactive protein;Fibrinogen; | — |
Countries
China
Contacts
Public ContactMou Zhongqing
Beijing Hospital
Outcome results
None listed